Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor

US5895783A · kind A · utility

Assignees

• SCHERING CORPORATION · US
• THE UNIVERSITY OF TEXAS · US

Inventors

• Robert E. Garfield · Goodyear, US
• Krzysztof Chwalisz · Berlin, DE
• Radoslaw Bukowski · Berlin, DE
• Chandra Yallampal Li · Houston, US

Key dates

• Filing date: Jul 16, 1993
• Grant date: Apr 20, 1999
• Expiry date: Jul 16, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI.sub.2 -mimetic, a thromboxane (TXA.sub.2) inhibitor, a compound possessing TXA.sub.2 -agonistic and TXA.sub.2 -inhibiting properties, a compound possessing TXA.sub.2 -antagonistic and PGI.sub.2 -memetic activities, and a TXA.sub.2 antagonist.