Bispecific reagents for AIDS therapy
US5897861A · kind A · utility
7Cited by
13References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 16, 1994 |
| Grant date | Apr 27, 1999 |
| Priority date | — |
| Expiry date | May 16, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6879
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bispecific molecules which react both with the high-affinity Fc.gamma. receptor (Fc.gamma.RI) of effector cells and with the human immunodeficiency virus (HIV), or component thereof are disclosed. Binding of these bispecific molecules to the Fc.gamma.RI is not blocked by the binding of the Fc region of IgG to that same receptor, as the bispecific molecules are specific for an epitope on the Fc.gamma.RI distinct from the Fc binding epitope. The bispecific molecules are useful for targeting human effector cells to a target on HIV. Also disclosed are methods of treating HIV infection using these bispecific molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.