Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
US5898029A · kind A · utility
19Cited by
3References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1994 |
| Grant date | Apr 27, 1999 |
| Priority date | — |
| Expiry date | Apr 12, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/436
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.