Pulsatile flow system for developing heart valves
US5899937A · kind A · utility
56Cited by
7References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1997 |
| Grant date | May 4, 1999 |
| Priority date | — |
| Expiry date | Mar 5, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2/2472
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A closed, sterile pulsatile flow loop for studying tissue valves. The system provides both a tool to examine heart valve leaflet fibroblast function and differentiation as these are affected by mechanical loading, as well as an apparatus to provide heart valves seeded with suitable cells. The sterile pulsatile flow system provides a left heart duplicator, which exposes viable tissue valves to a dynamic flow environment imitating that of the aortic valve.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.