Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
US5900237A · kind A · utility
4Cited by
1References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 4, 1996 |
| Grant date | May 4, 1999 |
| Priority date | — |
| Expiry date | May 4, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described and claimed are compounds of formula (I) wherein Y is a polypeptide, R.sub.1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C.sub.1-21 alkyl, alkene, or alkyne group, R.sub.2 is a side chain of a naturally occurring amino acid, and X is (a), (b), (c). Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.