Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them

US5900436A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Nirogi Venkata Satya Ramakrishna · Hyderabad, IN
• Arun Kumar Jain · Mumbai, IN
• Bansi Lal · Yellandu, IN
• Rao Venkata Satya Veerabhadra Vadlamudi · Yellandu, IN
• Anil Ghate · Thane, IN
• Ravindra Dattatraya Gupte · Jamkhed, IN
• Andreas Weichert · Egelsbach, DE
• Jan-Robert Schwark · Frankfurt am Main, DE

Key dates

• Filing date: Jul 28, 1997
• Grant date: May 4, 1999
• Expiry date: Jul 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: PA1 Indanylidineacetylguanidines I ##STR1## and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na.sup.+ /H.sup.+ exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.