Antibodies which bind the G-CSF receptor extracelluar domain and methods of treatment
US5902584A · kind A · utility
4Cited by
1References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1997 |
| Grant date | May 11, 1999 |
| Priority date | — |
| Expiry date | Jan 21, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a composition comprising antibodies or binding portions thereof which bind to a naturally occurring or recombinant G-CSF receptor extracellular domain, and reduce tyrosine phosphorylation of a JAK molecule. The invention also relates to methods of using this composition for inhibiting or decreasing tyrosine phosphorylation of a JAK kinase and for inhibiting or decreasing G-CSF interaction with its receptor. Also described are antibodies which bind to a G-CSF receptor extracellular domain and which are produced by immunizing an animal with cells transfected with DNA encoding a G-CSF receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.