Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets

US5902608A · kind A · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• East Carolina University · US

Inventors

• Marjorie S. Read · Durham, US
• Robert L. Reddick · Durham, US
• Arthur P. Bode · Greenville, US

Key dates

• Filing date: Dec 31, 1996
• Grant date: May 11, 1999
• Expiry date: Dec 31, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.