Modified phosphoramidite process for the production of modified nucleic acids

US5902878A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Heinz-Hartmut Seliger · Neu-Ulm, DE
• Sibylle Berner · Starnberg, DE
• Klaus Muhlegger · Polling, DE
• Herbert von der Eltz · Spaichingen, DE
• Hans-Georg Batz · Tutzing, DE

Key dates

• Filing date: Sep 19, 1997
• Grant date: May 11, 1999
• Expiry date: Sep 19, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.