Use of sesquiterpene lactones for treatment of severe inflammatory disorders

US5905089A · kind A · utility

Assignee

• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Daniel Hwang · Baton Rouge, US
• Nikolaus H. Fischer · Baton Rouge, US

Key dates

• Filing date: Apr 13, 1998
• Grant date: May 18, 1999
• Expiry date: Apr 13, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/365
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Sesquiterpene lactones are useful in suppressing the early proinflammatory cytokines, and in ameliorating septic shock and other severe inflammatory disorders. Sesquiterpene lactones with an .alpha.-methylene-.gamma.-lactone functional group suppress the expression of the inducible cyclooxygenase-2 and proinflammatory cytokines (Interleukin-1.alpha. and .beta., IL-1, and tumor necrosis factor-.alpha. (TNF.alpha.)) in mammalian macrophages stimulated with lipopolysaccharide. This suppression correlated with the inhibition of protein-tyrosine phosphorylation including the mitogen-activated protein kinases.