Preparation of aminomethyl-phenylimidazoles
US5905152A · kind A · utility
3Cited by
5References
14Claims
0Family size
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Key dates
| Filing date | Aug 6, 1997 |
| Grant date | May 18, 1999 |
| Priority date | — |
| Expiry date | Aug 6, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The aminomethyl-phenylimidazoles have useful properties as highly selective partial agonists or antagonists at brain dopamine receptor subtypes. A preferred compound prepared is 5-fluoro-2-4-(2-phenyl-1H-imidazol-5-yl)methyl!-1-piperazinyl!pyrimidine . Esters of the hydroxymethyl-phenylimidazoles are useful intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.