Process for producing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole using methyldithiocarbazinate and trifluoroacetic acid

US5905157A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Vijay C. Desai · Shawnee, US
• Peter E. Newallis · Leawood, US
• Vidyanatha A. Prasad · Leawood, US
• Herman Seifert · Bensberg, DE

Key dates

• Filing date: Dec 12, 1997
• Grant date: May 18, 1999
• Expiry date: Dec 12, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a process of making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. The process includes the steps of (a) reacting methyldithiocarbazinate with a molar excess of trifluoroacetic acid; and (b) removing the water and excess trifluoroacetic acid. Water and excess trifluoroacetic acid are preferably removed via distillation.