Process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane

US5905170A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Konrad Fischer · Odenthal, DE
• Oswald Wilmes · Recklinghausen, DE
• Dieter Arlt · Cologne, DE
• Carl Casser · Neunburg vorm Wald, DE
• Peter Maas · Puth, NL
• Pierre Louis Woestenborghs · Echt, NL
• Theo Van der Knaap · Grevenbicht, NL

Key dates

• Filing date: Mar 11, 1998
• Grant date: May 18, 1999
• Expiry date: Mar 11, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane by PA1 a) simultaneously reacting 4(5)-aminomethyl-1-methylcyclohexene (CMA), hydrocyanic acid and aqueous sulphuric acid at temperatures of 60.degree. C. to 120.degree. C., preferably 80.degree. C. to 120.degree. C. to form 1-formamido-1-methyl-3(4)-aminomethylcyclohexane (FMA) in a first stage, PA1 b) adding water and hydrolyzing 1-formamido-1-methyl-3 (4)-aminomethylcyclohexane (FMA) and unreacted hydrocyanic acid in a second stage and PA1 c) adding a base and isolating 1-amino-1-methyl-3 (4)-aminomethylcyclohexane (AMCA) by extraction from the reaction mixture obtained in the second stage of the reaction, optionally after removing of formic acid.