Lipidic vector for nucleic acid delivery
US5908777A · kind A · utility
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Key dates
| Filing date | Jun 23, 1995 |
| Grant date | Jun 1, 1999 |
| Priority date | — |
| Expiry date | Jun 23, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/285
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A simple, rapid method for creating a lipidic vector for delivery of a therapeutic molecule entails bringing the molecule into contact with a polycation, thereby forming a complex, and then mixing the complex with an anionic lipidic preparation. Tissue-specific targeting peptides, fusogenic peptides and nucleus-targeting peptides also can be added to the lipid preparation. The result is a stable lipidic vector of reduced immunogenicity and cytotoxicity. The vector also displays enhanced transfection activity.
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