Chlorhexidine gluconate-containing, stabilized aqueous pharmaceutical preparations
US5908865A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1997 |
| Grant date | Jun 1, 1999 |
| Priority date | — |
| Expiry date | May 13, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An aqueous pharmaceutical preparation is provided containing chloride ion and stably containing chlorhexidine gluconate, characterized in that said preparation further contains at least one pharmaceutically acceptable polycarboxylic acid of the formula I: EQU HOOC--(CR.sub.i 1 --CR.sub.i 2)n --COOH (I) wherein n is an integer 1, 2 or 3; i is a positive integer not more than n; R.sup.11 and R.sub.12, when n=1, independently from each other, are H, --OH or --COOH; each of R.sub.11, R.sub.12, R.sub.21 and R.sub.22, when n=2, is H, --OH or --COOH, but not all of them are H simultaneously; and each of R.sub.11, R.sub.12, R.sub.21, R.sub.22, R.sub.31 and R.sub.32, when n=3, is H, --OH or --COOH, but two adjacent carbons in no case contain four hydrogen atoms in total; or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.