Highly lipophilic camptothecin derivatives
US5910491A · kind A · utility
24Cited by
5References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1997 |
| Grant date | Jun 8, 1999 |
| Priority date | — |
| Expiry date | Aug 19, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.