Hormonal agent for skin treatment

US5910493A · kind A · utility

Assignee

• Jenapharm GmbH · DE

Inventors

• Siegfried Golbs · Leipzig, DE
• Michael Oettel · Jena, DE
• Michael Dittgen · Apolda, DE
• Thomas Graser · Erfurt, DE
• Christoph Luderschmidt · Plön, DE

Key dates

• Filing date: Sep 16, 1996
• Grant date: Jun 8, 1999
• Expiry date: Sep 16, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q19/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a combination of dienogest and an estrogen, as active ingredient. Methods for treatment of this type of skin condition include topical application of the composition including the dienogest which results in an outstanding sebosuppression, a drastic reduction of androstandiol glucuronide and a moderate competitive blockage of androgen receptor sites. Galenic formulations are described which limit and/or prevent the permeation of the active ingredient through the skin. The pharmaceutical preparation including the dienogest and conventional dermatologically acceptable carrier and auxiliary substances in the described galenic formulation advantageously provides a drastic reduction in androstandiol glucuronide and moderate androgen receptor blockage without passing through the skin barrier so that systemic effects including side reactions are substantially prevented.