Anhydro- and isomer-A-21978C cyclic peptides
US5912226A · kind A · utility
34Cited by
4References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 16, 1991 |
| Grant date | Jun 15, 1999 |
| Priority date | — |
| Expiry date | Dec 16, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Two new groups of A-21978C cyclic peptides, anhydro- and isomer-A21978C peptide derivatives, have antibacterial activity and are useful as intermediates. The two groups are prepared via transpeptidation of the parent cyclic peptides. Pharmaceutical formulations containing the new peptides as active ingredients and methods of treating infections caused by susceptible Gram-positive bacteria with the formulations are also provided. The invention also provides an antibacterial composition containing the new drug substance LY 146032 in substantially pure form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.