Anhydrous 1,4-Dihydropyridines and salts thereof

US5912351A · kind A · utility

Assignee

• Recordati S.A. Chemical and Pharmaceutical Company · CH

Inventors

• Amedeo Leonardi · Milano, IT
• Gianni Motta · Barlassina, IT

Key dates

• Filing date: May 10, 1996
• Grant date: Jun 15, 1999
• Expiry date: May 10, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention provides anhydrous 1,4-dihydropyridines and salts thereof, and a method for preparing them. The 1,4-dihydropyridines have Formula I: ##STR1## wherein: Ph is phenyl, PA1 Ar is: 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, PA1 A is a branched chain alkylene radical having from 2 to 6 carbon atoms, PA1 R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, PA1 R.sub.1 is hydrogen, hydroxy, or an alkyl radical having from 1 to 4 carbon atoms, and PA1 R.sub.2 is hydrogen, or methyl.