Biocompatible coating, medical device using the same and methods
US5914115A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 30, 1995 |
| Grant date | Jun 22, 1999 |
| Priority date | — |
| Expiry date | May 30, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S428/936
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention involves using a glow discharge plasma to functionalize a surface of medical devices such as catheters, particularly intracardial catheters, with covalently bound thermochemically reactive groups. The surface is further contacted with a bioactive agent, particularly antithrombogenic coatings, which is thermochemically covalently coupled to the reactive group to form a therapeutically effective coating. The selected bioactive agent is then covalently bound to the surface by thermochemical reaction with the surface reactive groups. In another embodiment, the functionalizing step comprises contacting the surface with a Langmuir-Blodgett film comprising an amphipathic compound and a bioactive agent and using a plasma to covalently crosslink the Langmuir-Blodgett film to the medical device surface and to the bioactive agent. Medical devices prepared by the subject methods are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.