Antibodies to a novel tissue inhibitor of metalloproteinases
US5914392A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 7, 1998 |
| Grant date | Jun 22, 1999 |
| Priority date | — |
| Expiry date | Jul 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a nucleic acid sequence which identifies and encodes a novel tissue inhibitor of metalloproteinases (TIMP-4) which was isolated from cells of human uterus. The invention provides for TIMP-4 antisense molecules and genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding TIMP-4. The invention also provides for purified TIMP-4; antibodies, antagonists and inhibitors which specifically bind TIMP-4; and pharmaceutical compositions and methods of treatment based on TIMP-4, its antagonists and inhibitors. The invention provides for diagnostic assays which utilize diagnostic compositions comprising nucleic acid sequences encoding to TIMP-4, or complements thereof, and antibodies which specifically bind to TIMP-4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.