Industrial process for the continuous preparation of sodium orthohydroxymandelate
US5914429A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 2, 1998 |
| Grant date | Jun 22, 1999 |
| Priority date | — |
| Expiry date | Mar 2, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In an industrial process for the manufacture of sodium orthohydroxymandelate by condensation of phenol in an inert atmosphere with glyoxylic acid in aqueous solution, in the presence of a tertiary amine and of catalytic quantities of a trivalent metal cation at a temperature below 100.degree. C., carried out continuously in at least two reactors (R1 . . . Rn) installed in series, the first being supplied by a first tank C1 containing the glyoxylic acid and the trivalent metal cations, and a second tank C2 containing the phenol and the tertiary amine, the reaction medium obtained at the outlet of the last of the at least two reactors and consisting of an aqueous phase and an organic phase is transferred into the first of two mixer-decanters (MD1 and MD2) installed in series, the aqueous phase of the first mixer-decanter MD1 is recovered in order to extract the expected sodium orthohydroxymandelate from it, while the organic phase that has come from MD1 is transferred into the second mixer-decanter MD2 and washed with water, and the organic phase of the second mixer-decanter MD2 is transferred to the second tank (C2).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.