Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use

US5916588A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Mircea C. Popescu · Plainsboro, US
• Alan L. Weiner · Lawrenceville, US
• Marie S. Recine · Hamilton Township, US
• Andrew S. Janoff · Yardley, US
• Leonard F. Estis · Coram, US
• Lynn D. Keyes · Upton, US
• Carl R. Alving · Bethesda, US

Key dates

• Filing date: May 25, 1995
• Grant date: Jun 29, 1999
• Expiry date: May 25, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55555
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.