Patent · US Expired

Target cell-specific non-viral vectors for inserting genes into cells, pharmaceutical compositions comprising such vectors and their use

US5916803A · kind A · utility

41Cited by

4References

11Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Hans-Harald Sedlacek · Marburg, DE
Hans-Dieter Klenk · Linden, DE
Thomas Kissel · Rochester, US
Rolf Muller · Marburg, DE

Key dates

Filing date	Feb 13, 1997
Grant date	Jun 29, 1999
Priority date	—
Expiry date	Feb 13, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/87
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Target cell-specific, non-viral vectors for inserting genes into cells, pharmaceuticals composition comprising such vectors, and methods of their use. Target cell-specific, non-viral vectors for inserting at least one gene into cells of an organism, comprising a complex comprising the following components: PA0 a) a non-viral carrier for the gene to be inserted, PA0 b) a ligand which can bind specifically to the desired target cell, PA0 c) a fusion protein for the penetration of the vector into the cytoplasm of the target cell, and PA0 d) the gene to be introduced are disclosed. Vectors of this nature are used, for example, in gene therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.