Trans cyclopentanyl deazaadenyl analogs useful as immunosuppressants
US5916892A · kind A · utility
0Cited by
16References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 1997 |
| Grant date | Jun 29, 1999 |
| Priority date | — |
| Expiry date | Nov 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, PA1 Y.sub.3, Y.sub.5 and Y.sub.9 are each nitrogen and Y.sub.7 and Y.sub.8 are a CH group, PA1 R is a hydrogen, a C.sub.1 -C.sub.7 alkyl acyl or aryl acyl, PA1 Q is NH.sub.2, halogen or hydrogen, PA1 Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.