Processes and intermediates for preparing 5, 7-dihydro-3-2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo-4, 5-F!-1, 2-benzisoxazol-6-one
US5916902A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1997 |
| Grant date | Jun 29, 1999 |
| Priority date | — |
| Expiry date | Apr 16, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process for preparing the compound having the formula ##STR1## which comprises i) heating the compound of formula ##STR2## wherein R.sup.3 is R.sup.4 or benzyl and R.sup.4 is R.sup.5 C(.dbd.O), R.sup.5 C(.dbd.O) or R.sup.5 SO.sub.2 wherein R.sup.5 is (C.sub.1 -C.sub.6)alkyl or (C.sub.6 -C.sub.10)aryl(C.sub.1 -C.sub.6)alkyl; at an elevated temperature in the presence of a base with the proviso that when R.sup.3 in the resultant product is R.sup.4 said product is ii) further treated with an aqueous mineral acid at an elevated temperature followed by iii) treatment of the product of ii) with a) a benzylating agent in the presence of a base or b) benzaldohyde in the presence of a reducing agent and an acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.