Copolymers with polyester polycarbonate blocks containing poly(caprolactone) segments, and use thereof for the preparation of biodegradable matrices

US5916998A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Paolo Ferruti · Milano, IT
• Maurizio Penco
• Elisabetta Ranucci · Brescia, IT

Key dates

• Filing date: Feb 7, 1997
• Grant date: Jun 29, 1999
• Expiry date: Feb 7, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G63/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to block copolymers of general formula (I) EQU ----O--CO--O--A--O--CO--O--B--!.sub.a -- (I) where a is an integer between 2 and 300 inclusive; PA1 A and B, which may be the same or different, are blocks which can be obtained by reaction between a bis(chloroformate) of oligomeric poly(caprolactone) and a polyester residue of formula (II) EQU HO----R.sub.1 --CO--O!.sub.x ----R.sub.2 --CO--O--!.sub.y --H (II) where R.sub.1 and R.sub.2, which may be the same or different, are each an aliphatic hydrocarbon residue with a linear or branched chain having from 1 to 4 carbon atoms; x and y are integers from 1 to 50, in any possible ratio from 0 to 1; PA1 the groups --R.sub.1 --COO-- and --R.sub.2 --COO-- being randomly distributed in the polyester residue.