Diphtheria toxin vaccines bearing a mutated R domain

US5917017A · kind A · utility

Assignees

• President and Fellows of Harvard College · US
• The Regents of the University of California · US

Inventors

• R. John Collier · Wellesley, US
• Wei Hai Shen · Boston, US
• David S. Eisenberg · Los Angeles, US
• Seunghyon Choe · Calabasas, US

Key dates

• Filing date: Jun 8, 1994
• Grant date: Jun 29, 1999
• Expiry date: Jun 8, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.