Process for removing endotoxins
US5917022A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 13, 1995 |
| Grant date | Jun 29, 1999 |
| Priority date | — |
| Expiry date | Oct 13, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/765
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the removal of endotoxin from a biological product such as proteins for therapeutic use, blood plasma fractions, and albumin solutions that contains endotoxins, which comprises contacting said biological product with a cross-linked hydrophilic matrix comprising a copolymer of allyl dextran and N,N'-methylene bisacrylamide under conditions effective to bind endotoxins in said biological product to said matrix, wherein the total amount of endotoxin in said biological product does not exceed the absorptive capacity of said cross-linked hydrophilic matrix, and recovering purified biological product from which endotoxin has been removed as a result of said binding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.