N-hydroxy-dibenzb,e!oxepinalkylamines, n-hydroxy-dibenzb,e!oxepinalkanoic acid amides and related heterocyclic analogues
US5917057A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1998 |
| Grant date | Jun 29, 1999 |
| Priority date | — |
| Expiry date | Feb 27, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D313/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to N-hydroxy-dibenzb,e!oxepinalkylamines, N-hydroxy-dibenzb,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R.sup.1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R.sup.2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.