Stable lyophilized pharmaceutical preparations of G-CSF

US5919443A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Uwe Michaelis · Darmstadt, DE
• Rainer Rudolph · Waldshut-Tiengen, DE
• Gerhard Winter · Dossenheim, DE
• Heinrich Woog · Hemsbach, DE

Key dates

• Filing date: Jun 15, 1995
• Grant date: Jul 6, 1999
• Expiry date: Jun 15, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns lyophilized pharmaceutical preparations of G-CSF that contain maltose, raffinose, sucrose, trehalose or amino sugar as stabilizing agents. In additon the invention concerns a process for the production of stabilized lyophilisates as well as the use of maltose, raffinose, sucrose, trehalose or amino sugar as stabilizing agents of pharmaceutical agents containing G-CSF.