Derivatization of solid supports and methods for oligomer synthesis

US5919523A · kind A · utility

Assignee

• AFFYMETRIX, INC. · US

Inventors

• Steven A. Sundberg · San Francisco, US
• Jeffrey W. Jacobs · Fremont, US
• John Schullek · Santa Clara, US
• Glenn McGall · Mountain View, US
• Andrei Darievich Mirzabekov · Westmont, US
• Edward Timofeey · Moscow, RU
• David Fujimoto · Hayward, US
• Christopher P. Holmes · Sunnyvale, US
• Hua Yang · Delta, CA

Key dates

• Filing date: Oct 24, 1997
• Grant date: Jul 6, 1999
• Expiry date: Oct 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.