Oligonucleotide therapeutic agent and methods of making same
US5919619A · kind A · utility
49Cited by
3References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 31, 1995 |
| Grant date | Jul 6, 1999 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/321
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a bological component, such as a protein, of the organism. The oligonucleotide has about fourteen bases or more, such as twenty-three bases, and can be a deoxyribonucleotide. The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.