Aqueous pharmaceutical preparations of G-CSF with a long shelf life

US5919757A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Uwe Michaelis · Darmstadt, DE
• Rainer Rudolph · Waldshut-Tiengen, DE
• Gerhard Winter · Dossenheim, DE
• Heinrich Woog · Hemsbach, DE

Key dates

• Filing date: May 15, 1997
• Grant date: Jul 6, 1999
• Expiry date: May 15, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aqueous pharmaceutical preparations of G-CSF are disclosed that are stable on storage and a buffer selected from the group consisting of a salt of citrate, maleate, a combination of phosphate and citrate, and arginine; and at least one surfactant.