Hydroximic acid derivatives, pharmaceutical compositions containing them, and processes for preparing the same
US5919796A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1996 |
| Grant date | Jul 6, 1999 |
| Priority date | — |
| Expiry date | Nov 5, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/78
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Hydroximic acid derivatives possess anti-ischemic effects, and therefore, they are useful for treating ischemic states and diseases, such as myocardial ischemia (which may be induced by occlusion of coronary arteries). These derivatives include compounds of formula (I): ##STR1## wherein: X represents a halogen; Z represents an aromatic group, a pyridinyl group, a picolyl group, or a lutidyl group; and R represents an --A--N(R.sub.1)R.sub.2 group, wherein: PA1 R.sub.1 and R.sub.2 represent, independently from each other, hydrogen or an alkyl group; PA1 or R.sub.1 and R.sub.2, together with the adjacent nitrogen atom, form a 5- to 7-membered, PA1 saturated heterocyclic group optionally containing an additional nitrogen, oxygen, PA1 or sulfur atom, the heterocyclic group optionally being substituted by at least one alkyl group; and A represents a straight or branched chain alkylene group, as well as pharmaceutically acceptable acid addition salts thereof. The invention further relates to processes for preparing the above noted compounds, and pharmaceutical compositions containing these compounds or their pharmaceutically acceptable acid addition salts as an active ingredient. Addition…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.