Benzothiazoles and benzoxazoles, drugs containing them, their use and methods of preparing them

US5919807A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Peter Muller · Mittelbiberach, DE
• Rudolph Hurnaus · Biberach, DE
• Roland Maier · Biberach an der Riß, DE
• Michael Mark · Biberach an der Riß, DE
• Bernhard Eisele · Biberach, DE
• Ralph-Michael Budzinski · Biberach, DE
• Leo Thomas · Biberach, DE
• Gerhard Hallermayer · Biberach an der Riß, DE

Key dates

• Filing date: Oct 28, 1997
• Grant date: Jul 6, 1999
• Expiry date: Oct 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to benzothiazoles and benzoxazoles of general formula ##STR1## wherein R.sup.1 to R.sup.3, X, Z and n are defined as in claim 1, the enantiomers, diastereomers and salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.