Adenoviruses having altered hexon proteins
US5922315A · kind A · utility
67Cited by
1References
10Claims
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Assignee
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Key dates
| Filing date | Jan 24, 1997 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | Jan 24, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10345
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An adenovirus wherein at least one portion of at least one loop region of the hexon is changed. In one embodiment, the adenovirus, prior to modification, is of a first serotype, and at least a portion of at least one loop region of the hexon is removed and replaced with at least a portion of at least one loop region of the hexon of an adenovirus of a second serotype. Such modified adenoviruses do not have epitopes which are recognized by neutralizing antibodies to the unmodified adenovirus of the first serotype.
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