Composition and method of preparing microparticles of water-insoluble substances
US5922355A · kind A · utility
115Cited by
7References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 29, 1997 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | Sep 29, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/931
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Submicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.