Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation

US5922717A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Helmut Pieper · Lohr am Main, DE
• Volkhard Austel · Biberach, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Gunter Linz · Mittelbiberach, DE
• Brian Guth · Warthausen, DE
• Johannes Weisenberger · Biberach, DE

Key dates

• Filing date: Dec 21, 1995
• Grant date: Jul 13, 1999
• Expiry date: Dec 21, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.