Benzimidazole compounds and their use as modulators of the GABA.sub.A receptor complex
US5922725A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 23, 1997 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | Dec 23, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF.sub.3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl; one of R.sup.6 and R.sup.7 is hydrogen and the other is --CR'.dbd.NOR", wherein R' and R" each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl. The compounds are useful for the treartment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.