4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators
US5922735A · kind A · utility
9Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 5, 1998 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | Oct 5, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided novel substituted 4-aryl-3-hydroxyquinolin-2-one derivatives of the formula ##STR1## wherein R is hydrogen or methyl; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, bromo, chloro or trifluoromethyl, and when R.sup.1, R.sup.3 and R.sup.4 are hydrogen, R.sup.2 is nitro; PA1 R.sup.5 is hydrogen or methyl; and PA1 R.sup.6 is bromo or chloro; or a nontoxic pharmaceutically acceptable salt thereof, which are openers of the large-conductance calcium-activated potassium channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.