Heterocyclylcarbonyl substituted benzofuranyl-ureas

US5922740A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gabriele Braunlich · Wuppertal, DE
• Mazen Es-Sayed · Langenfeld, DE
• Rüdiger Fischer · Pulheim, DE
• Burkhardt Fugmann · Ratingen, DE
• Rolf Henning · Wuppertal, DE
• Michael Sperzel · Wuppertal, DE
• Ulrich Nielsch · Wuppertal, DE
• Graham Sturton · Maidenhead, GB

Key dates

• Filing date: Dec 4, 1996
• Grant date: Jul 13, 1999
• Expiry date: Dec 4, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heterocyclyclcarbonyl substituted benzofuranyl-ureas are prepared by reacting heterocyclylcarbonyl substituted 3-amino-benzofuranes with appropriate isocyanates or isothiocyanates. The unsubstituted ureas are transferred into substituted ureas by usual methods of substitution. The heterocyclylcarbonyl substituted benzofuranyl-ureas are useful as active ingredients in medicaments particularly for the treatment of acute and chronical inflammatory processes.