Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same

US5922751A · kind A · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• David Cavalla · Cambridge, GB
• Mark Chasin · Manalapan, US
• Lloyd J. Dolby · Eugene, US
• Richard William Frith · Cambridge, GB

Key dates

• Filing date: Jan 10, 1997
• Grant date: Jul 13, 1999
• Expiry date: Jan 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-cyclopentyloxy-4-methoxy-benzylamino)-4-hydroxymethyl pyrazole and 3-(3-cyclopentyloxy-4-methoxybenzylamino)-4-methoxymethylpyrazole.