Immunomodulator, cell adhesion inhibtor, and agent for treating, and preventing autoimmune diseases
US5922755A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 6, 1996 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | May 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 4H-1-benzopyran-4-one derivative of the general formura 1!, ##STR1## or a salt thereof exerts excellent effects on immunomodulation and cell adhesion inhibition, and is further expected to have the effect of relieving autoimmune diseases at a level comparable to that of steroids. Thus, the compound of the general formula 1! is useful in the teatment and prevention of autoimmune diseases fundamentally caused by immunopathy or unusually accelerated cell adhesion, for example, chronic rheumatoid arthritis, systemic lupus erythematosus, scleroderma, mixed connective tissue disease,polyarteritis nodosa, polymyositis/dermatomyositis, Sjogren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, serious adynamia, ulcerative colitis, chronic active hepatitis, autoimmune hemolytic anemia idiopathic thrombocytopenic purpura and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.