Process for making mesna, dimesna and derivatives thereof
US5922902A · kind A · utility
5Cited by
3References
4Claims
0Family size
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Key dates
| Filing date | Jun 30, 1998 |
| Grant date | Jul 13, 1999 |
| Priority date | — |
| Expiry date | Jun 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/3808
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals. The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.