Mixed solvent mutually enhanced transdermal therapeutic system
US5925372A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1991 |
| Grant date | Jul 20, 1999 |
| Priority date | — |
| Expiry date | Jun 26, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A transdermal drug delivery system comprising PA1 (i) an occlusive, impermeable polymeric backing layer; PA1 (ii) a drug depot on one side thereof; PA1 (iii) a removable, occlusive covering layer over said drug depot; and PA1 (iv) an adhesive means by which said delivery system, absent said removable covering layer may be affixed to an intended patient; said drug depot containing a drug formulation comprising a transdermally administrable pharmaceutically acceptable pharmaceutically active agent or a precursor thereof, water and lower alkanol; said active agent or precursor thereof being present in a pharmaceutically effective amount; said lower alkanol and said water being present in a volume:volume ratio of from 30:70 up to less than 95:5 such that said lower alkanol, water and drug are delivered to a patient's skin, which patient has applied said system absent said removable covering layer to said patient's skin, in amounts that said drug is delivered in a transdermally administrable efficacious amount, said water has an activity at said patient's skin of about 0.4 to about 0.95 and said lower alkanol, at said patient's skin, has an activity of 0.3 to about 0.9, and wherein, onc…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.