Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
US5925648A · kind A · utility
5Cited by
3References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 29, 1997 |
| Grant date | Jul 20, 1999 |
| Priority date | — |
| Expiry date | Jul 29, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.