Pharmaceutical formulation for subcutaneous intramuscular or intradermal administration of factor VIII

US5925739A · kind A · utility

Assignee

• Pharmacia & UpJohn AB · SE

Inventors

• Jack Spira · Tyresö, SE
• Lars Widlund
• Thomas Österberg · Linköping, SE
• Brita Sjostrom · Nacka, SE
• Marianne Mikaelsson · Bromma, SE

Key dates

• Filing date: Sep 17, 1996
• Grant date: Jul 20, 1999
• Expiry date: Sep 17, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration comprising coagulation factor VIII or factor IX and use thereof for manufacture of a medicament for treating haemophilia A or B. The formulation comprises coagulation factor VIII or factor IX with an activity of at least 200 IU/ml and an additive increasing the bio-availability of factor VIII or factor IX. Tests with factor VIII gives a therapeutic level of active factor VIII in the blood stream for a surprisingly long period of time after subcutaneous, intramuscular or intradermal administration. The factor VIII is suitably a highly purified recombinant factor VII, and preferably a deletion derivative thereof, which can be used for the manufacture of a medicament for subcutaneous administration.