Functional terpyridine-metal complexes, a process for the preparation thereof and oligonucleotide conjugates with terpyridine-metal complexes

US5925744A · kind A · utility

Assignee

• Novartis Finance Corporation · US

Inventors

• Robert Haner · Fehren, CH
• Jonathan Hall · Dornach, CH
• Dieter Husken · Glückstadt, DE
• Uwe Pieles · Schliengen, DE
• Heinz Ernst Moser · San Mateo, US

Key dates

• Filing date: Jul 28, 1997
• Grant date: Jul 20, 1999
• Expiry date: Jul 28, 2017

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2458/40
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to cyclic terpyridine-lanthanide complexes having 8 nitrogen atoms and 10 carbon atoms in the macrocycle and containing a functional group in the terpyridine moiety. The invention also relates to a process for the preparation of cyclic terpyridine-lanthanide complexes through the condensation of terpyridine hydrazines with pyridine-2,6-dialdehydes or -ketones. The compounds can be complexed with oligonculeotides and are useful in the sequence-specific cleavage of RNA.