Polyethoxylated castor oil, process of making the same and formulations thereof

US5925776A · kind A · utility

Assignee

• Schein Pharmacetical, Inc. · US

Inventors

• Aleksandr Nikolayev · Maple Shade, US
• Fakrul A. A. Sayeed · Mundelein, US
• Rupa Iyer · Marlton, US
• Mitchell Garber · Calabasas, US
• Robert C. Butterhof · Branchville, US
• Todd M. Hoyer · Trenton, US
• Marvin Samson · Cherry Hill, US

Key dates

• Filing date: Dec 24, 1997
• Grant date: Jul 20, 1999
• Expiry date: Dec 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polyethoxylated castor oil with a low cation content are claimed, along with particular methods for achieving such low cation content polyethoxylated castor oil. One method of production of such a low cationic content polyethoxylated castor oil according to the invention is to pre-treat the polyethoxylated castor oil with a strong cationic exchange resin to remove a substantial portion of the cations present in an untreated polyethoxylated castor oil. The low cationic content polyethoxylated castor oil of the invention can then be utilized to prepare formulations of various agents which are found to be sensitive to the previously commercially available polyethoxylated castor oil (CREMOPHOR EL.RTM.).